Maternal-engineered nanomaterial exposure disrupts progeny cardiac function and bioenergetics

In conclusion, gestational nano-exposure significantly impairs the functional capabilities of the heart through cardiomyocyte impairment, which is associated with mitochondrial dysfunction.
NEW & NOTEWORTHY Cardiac function is evaluated, for the first time, in progeny following maternal nanomaterial inhalation. The findings indicate that exposure to nano-sized titanium dioxide (nano-TiO2) during gestation negatively impacts cardiac function and mitochondrial respiration and bioenergetics. We conclude that maternal nano-TiO2 inhalation contributes to adverse cardiovascular health effects, lasting into adulthood.

Source: AJP: Heart and Circulatory Physiology - February 28, 2017 Category: Cardiology Authors: Hathaway, Q. A., Nichols, C. E., Shepherd, D. L., Stapleton, P. A., McLaughlin, S. L., Stricker, J. C., Rellick, S. L., Pinti, M. V., Abukabda, A. B., McBride, C. R., Yi, J., Stine, S. M., Nurkiewicz, T. R., Hollander, J. M. Tags: RESEARCH ARTICLE Source Type: research