High aminopeptidase A activity contributes to blood pressure control in ob/ob mice by AT2 receptor-dependent mechanism

In this study, we reported an increased angiotensin III generation in the circulation of ob/ob mice caused by a high aminopeptidase A activity. These findings are associated with an increased natriuresis found in these mice and support the role of renin-angiotensin-aldosterone system as additional mechanism regulating blood pressure in this genetic obese strain.

Source: AJP: Heart and Circulatory Physiology - February 28, 2017 Category: Cardiology Authors: Morais, R. L., Hilzendeger, A. M., Visniauskas, B., Todiras, M., Alenina, N., Mori, M. A., Araujo, R. C., Nakaie, C. R., Chagas, J. R., Carmona, A. K., Bader, M., Pesquero, J. B. Tags: RESEARCH ARTICLE Source Type: research