Association of serum HMGB2 level with MACE at 1 mo of myocardial infarction: Aggravation of myocardial ischemic injury in rats by HMGB2 via ROS

In conclusion, increased serum HMGB2 levels are associated with MI severity and MACE at 1 mo. HMGB2 promotes myocardial ischemic injury in rats and hypoxic H9C2 cell damage via ROS provoked by RAGE.
NEW & NOTEWORTHY We demonstrate that serum high-mobility group box 2 is associated with major adverse cardiac events at 1 mo in myocardial infarction patients. Mechanistically, high-mobility group box 2 promotes reactive oxygen species production via receptor for advanced glycation end products signaling in ischemic myocardium, thereby aggravating cell apoptosis, inflammation, and autophagosome clearance impairment. This study reveals that high-mobility group box 2 is a novel factor enhancing ischemic injury in myocardial infarction.

Source: AJP: Heart and Circulatory Physiology - February 28, 2017 Category: Cardiology Authors: Liu, Z. H., Dai, D. P., Ding, F. H., Pan, W. Q., Fang, Y. H., Zhang, Q., Li, M., Yang, P., Wang, X. Q., Shen, Y., Wang, L. J., Yan, X. X., He, Y. H., Yang, K., Zhang, R. Y., Shen, W. F., Chen, Y., Lu, L. Tags: RESEARCH ARTICLE Source Type: research