The interaction of estrogen and CSE/H2S pathway in the development of atherosclerosis

This study provides new insights into the interaction of H2S and estrogen signaling pathways on the regulation of cardiovascular functions. NEW & NOTEWORTHY Female cystathionine -lyase (CSE)-knockout mice have significantly lower plasma estrogen levels and more severe early atherosclerotic lesion than female wild-type mice. H2S production in liver and vascular tissues is enhanced by estrogen via its stimulatory effect on CSE activity. The antiatherosclerotic effect of estrogen is mediated by CSE-generated H2S.
Source: AJP: Heart and Circulatory Physiology - Category: Cardiology Authors: Tags: RESEARCH ARTICLE Source Type: research