Reduced density and altered regulation of rat atrial L-type Ca2+ current in heart failure

In conclusion, reduction in PKA-dependent regulation did not contribute to downregulation of atrial ICaL in heart failure. NEW & NOTEWORTHY Whole cell recording of L-type Ca2+ currents in atrial myocytes from rat hearts subjected to coronary artery ligation compared with those from sham-operated controls reveals marked reduction in current density in heart failure without change in channel subunit expression and associated with altered phosphorylation independent of protein kinase A.

http://ajpheart.physiology.org/cgi/content/abstract/312/3/H384?rss=1

Source: AJP: Heart and Circulatory Physiology - February 28, 2017 Category: Cardiology Authors: Bond, R. C., Bryant, S. M., Watson, J. J., Hancox, J. C., Orchard, C. H., James, A. F. Tags: RESEARCH ARTICLE Source Type: research