Effect of Diindolylmethane on Estrogen-related Hormones, Metabolites and Tamoxifen Metabolism: Results of a Randomized, Placebo-controlled Trial

Conclusions In this first large study of DIM in the setting of breast cancer chemoprevention, a favorable shift in estrogen metabolism and SHBG was demonstrated. However, the reduction in tamoxifen metabolites raises concern regarding the potential interaction between DIM and tamoxifen, an area in need of continued research. Impact Given the widespread and generally unsupported use of dietary supplementation by breast cancer survivors, these data will help to inform the use of DIM as a dietary supplement for breast cancer patients receiving tamoxifen.

Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Thomson, C., Chow, S., Roe, D., Wertheim, B., Chalasani, P., Altbach, M., Thompson, P., Stopek, A., Maskaranic, G. Tags: ASPO 41st Annual Meeting Abstracts Source Type: research