DNA Methylation-Derived Neutrophil-to-Lymphocyte Ratio: An Epigenetic Tool to Explore Cancer Inflammation and Outcomes

Conclusions: These results mean that our current understanding of mature leukocyte methylomes is sufficient to allow researchers and clinicians to apply epigenetically based analyses of NLR in clinical and epidemiologic studies of cancer risk and survival.
Impact: As cytologic measurements of NLR are not always possible (i.e., archival blood), mdNLR, which is computed from DNA methylation signatures alone, has the potential to expand the scope of epigenome-wide association studies. Cancer Epidemiol Biomarkers Prev; 26(3); 328–38. ©2016 AACR.

Source: Cancer Epidemiology Biomarkers and Prevention - February 28, 2017 Category: Cancer & Oncology Authors: Koestler, D. C., Usset, J., Christensen, B. C., Marsit, C. J., Karagas, M. R., Kelsey, K. T., Wiencke, J. K. Tags: Research Articles Source Type: research