Development of an Automaton Model of Rotational Activity Driving Atrial Fibrillation

Atrial fibrillation (AF) is difficult to treat effectively, owing to uncertainty in where to best ablate to eliminate arrhythmogenic substrate. A model providing insight into the electrical activation events would be useful to guide catheter ablation strategy.MethodA two-dimensional, 576 ×576 node automaton was developed to simulate atrial electrical activity. The substrate field was altered by the presence of differing refractory period at varying locations. Fibrosis was added in the form of short, randomly positioned lines of conduction block.

Source: Computers in Biology and Medicine - February 28, 2017 Category: Bioinformatics Authors: E.J. Ciaccio, A.B. Biviano, E.Y. Wan, N.S. Peters, H. Garan Source Type: research