G1 cyclins protect pluripotency

Nature Cell Biology 19, 149 (2017). doi:10.1038/ncb3480 Authors: Julia Arand & Julien Sage G1 cyclins are considered essential for DNA replication and cell division. A recent report now shows that some cells can cycle in the absence of G1 cyclins. In embryonic stem cells and cancer cells, G1 cyclins are required to activate cyclin-dependent kinases to phosphorylate core pluripotency factors and maintain pluripotency.

http://feeds.nature.com/~r/ncb/rss/current/~3/OI-Dfkj9kUU/ncb3480

Source: Nature Cell Biology - February 27, 2017 Category: Cytology Authors: Julia Arand Julien Sage Tags: News and Views Source Type: research