Metabolic pattern formation in the tumor microenvironment

Metabolic alterations including increased glycolysis are a common feature of many cancers. In their recent study, Lowengrub, Waterman, and colleagues (Lee et al, 2017) report a spatial pattern of glycolysis in solid tumors that occurs within the tumor microenvironment. This spatial organization is linked to gradients derived from Wnt signaling and nutrient availability that mediate a reaction-diffusion mechanism and is consistent with a Turing-type model of spatial localization.

Source: Molecular Systems Biology - February 8, 2017 Category: Molecular Biology Authors: Dai, Z., Locasale, J. W. Tags: Cancer, Quantitative Biology & Dynamical Systems, Signal Transduction News [amp ] Views Source Type: research