Mathematical modeling of the effects of glutathione on arsenic methylation

Conclusions: The mathematical model aids in the interpretation of data from recent experimental studies and showsthat the Challenger pathway of arsenic methylation, supplemented by the glutathione effects describedabove, is sufficient to understand and predict recent experimental data. More experimental studiesare needed to explicate the detailed mechanisms of action of glutathione on arsenic methylation.Recent experimental work on the effects of glutathione on arsenic methylation and our modelingstudy suggest that supplements that increase hepatic glutathione production should be considered asstrategies to reduce adverse health effects in affected populations.
Source: Theoretical Biology and Medical Modelling - Category: Biomedical Science Authors: Source Type: research