Distinctive genomic signature of neural and intestinal organoids from familial Parkinson's disease patient ‐derived induced pluripotent stem cells

ConclusionWe provide the first evidence that LK2GS also causes significant changes in gene expression in the intestinal cells. These hNES and hIO models from the same genetic background of PD patients could be invaluable resources for understanding PD pathophysiology and for advancing the complexity of in vitro models with 3D expandable organoids.This article is protected by copyright. All rights reserved.

Source: Neuropathology and Applied Neurobiology - November 30, 2016 Category: Neurology Authors: Mi ‐Young Son, Hyuna Sim, Ye Seul Son, Kwang Bo Jung, Mi‐Ok Lee, Jung‐Hwa Oh, Sun‐Ku Chung, Cho‐Rok Jung, Janghwan Kim Tags: Original Article Source Type: research