Hypo-methylation mediates chromosomal instability in pancreatic NET

In conclusion, our data indicate that epigenetic changes are crucial steps in the progression of PanNETs loss and suggest that DNA methylation is the mechanism via which CIN is induced, allowing clonal expansion and selection.

Source: Endocrine-Related Cancer - February 23, 2017 Category: Endocrinology Authors: Marinoni, I., Wiederkeher, A., Wiedmer, T., Pantasis, S., Di Domenico, A., Frank, R., Vassella, E., Schmitt, A., Perren, A. Tags: Research Source Type: research