Anti ‐diabetic activities of cis‐ and trans‐2,3,5,4′‐tetrahydroxystilbene 2‐O‐β‐glucopyranoside from Polygonum multiflorum

Conclusion: Cis‐THSG can be an enriched bioactive ingredient in PM roots from post‐processing and is significantly more effective against hyperglycemia than trans‐THSG. One of the effective pathways was through inhibition of PEPCK.

Trans‐2,3,5,4′‐tetrahydroxystilbene 2‐O‐β‐glucopyranoside (trans‐THSG) is the major active compound in a medicinal food in Asia, Polygonum multiflorum (PM), and it can be induced through UV light to cis‐THSG, which mimics the traditional process of PM. Cis‐THSG can be an enriched bioactive ingredient in PM roots from post‐processing after PM harvesting and is significantly more effective against hyperglycemia than trans‐THSG. One of the effective pathways was through inhibition of phosphoenopyruvate carboxykinase (PEPCK), an important enzyme in gluconeogenesis.

Source: Nahrung / Food - February 23, 2017 Category: Nutrition Authors: Wenping Tang, Shiming Li, Yue Liu, Jia ‐Ching Wu, Min‐Hsiung Pan, Mou‐Tuan Huang, Chi‐Tang Ho Tags: Research Article Source Type: research