Untangling the genetics from the epigenetics in pancreatic cancer metastasis

Nature Genetics 49, 323 (2017). doi:10.1038/ng.3798 Authors: Christopher R Vakoc & David A Tuveson Comparative genomic analyses of primary tumors and metastases within individuals with pancreatic cancer have exposed the complex clonal dynamics that underlie the dissemination of cancer cells to distant sites. Recent studies implicate non-genetic mechanisms in this process, particularly fluctuations in chromatin states and metabolism, which can endow rare cells within a primary tumor with metastatic potential.

http://feeds.nature.com/~r/ng/rss/current/~3/l5FdvXdf87k/ng.3798

Source: Nature Genetics - February 23, 2017 Category: Genetics & Stem Cells Authors: Christopher R Vakoc David A Tuveson Tags: News and Views Source Type: research