Hypothalamic CRFR1 is essential for HPA axis regulation following chronic stress

Nature Neuroscience 20, 385 (2017). doi:10.1038/nn.4491 Authors: Assaf Ramot, Zhiying Jiang, Jin-Bin Tian, Tali Nahum, Yael Kuperman, Nicholas Justice & Alon Chen The hypothalamic–pituitary–adrenal axis is a pivotal component of an organism's response to stressful challenges, and dysfunction of this neuroendocrine axis is associated with a variety of physiological and psychological pathologies. We found that corticotropin-releasing factor type 1 receptor within the paraventricular nucleus of the hypothalamus is an important central component of hypothalamic–pituitary–adrenal axis regulation that prepares the organism for successive exposure to stressful stimuli.
Source: Nature Neuroscience - Category: Neuroscience Authors: Tags: Brief Communication Source Type: research