Treatment with alpha ‐galactosylceramide protects mice from early onset of nonalcoholic steatohepatitis: Role of intestinal barrier function

ConclusionTaken together, our data suggest that the protective effects of αGalCer against the development of a diet‐induced NASH in mice are associated with a protection against the increased translocation of intestinal bacterial endotoxins associated with the development of NASH. Chronic intake of a Western‐style diet leads to impairments of intestinal barrier function and increased translocation of bacterial endotoxins and subsequently resulting in the development of liver steatosis and inflammation. The protective effects of alpha‐galactosylceramide against the onset of Western‐style diet‐induced nonalcoholic steatohepatitis in mice are associated with a protection against the increased translocation of intestinal bacterial endotoxins and as a result against the accumulation of lipids and elevation of markers of inflammation in the liver.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fmnfr.201600985

Source: Nahrung / Food - February 21, 2017 Category: Nutrition Authors: Anna Janina Engstler, Cathrin Sellmann, Cheng Jun Jin, Annette Brandt, Kathleen Herz, Josephine Priebs, Ina Bergheim Tags: Research Article Source Type: research