Whole-genome profiling highlights the molecular complexity underlying eccentric cardiac hypertrophy

Conclusions:
Our results indicate that eccentric remodeling is a far more complex process than concentric remodeling. This study highlights the importance of several key biological functions early in the course of VO, including regulation of matrix, metabolism, cell proliferation, and contractile function. Thus, the results of this analysis will inform the ongoing search for new treatments to prevent the progression to heart failure in VO.

Source: Therapeutic Advances in Cardiovascular Disease - May 14, 2014 Category: Cardiology Authors: Barnes, J., Pat, B., Chen, Y.-W., Powell, P. C., Bradley, W. E., Zheng, J., Karki, A., Cui, X., Guichard, J., Wei, C.-C., Collawn, J., Dell'Italia, L. J. Tags: Original Research Source Type: research