DNA Methylation program in normal and alcohol-induced thinning cortex

While cerebral underdevelopment is a hallmark of fetal alcohol spectrum disorders (FASD), the mechanism(s) guiding the broad cortical neurodevelopmental deficits are not clear. DNA methylation is known to regulate early development and tissue specification through gene regulation. Here, we examined DNA methylation in the onset of alcohol-induced cortical thinning in a mouse model of FASD. C57BL/6J mice were administered a 4% alcohol (v/v) liquid diet from embryonic (E) days 7 –16, and their embryos were harvested at E17, along with isocaloric liquid diet and lab chow controls.

Source: Alcohol - February 17, 2017 Category: Addiction Authors: Nail Can Öztürk, Marisol Resendiz, Hakan Öztürk, Feng C. Zhou Source Type: research