Preparation and Optimization of Fast Dissolving Film of Naratriptan Hydrochloride.

Preparation and Optimization of Fast Dissolving Film of Naratriptan Hydrochloride. Recent Pat Drug Deliv Formul. 2017 Feb 12;: Authors: Koradia KD, Sidhdhapara PT, Sheth NR Abstract BACKGROUND AND OBJECTIVE: Naratriptan is second-generation triptan class of antimigraine drug which selectively bind with 5-HT(1B/1D) receptor. It is widely used to treat the migraine attack due to its better tolerability and lower recurrence rate as compared to other triptans. Despite of the applicability, Naratriptan also have several drawback like slow onset of action and fist pass metabolism which reduce its efficacy. In order to increase the efficacy of naratriptan fast dissolving film is prepared. METHOD: Fast dissolving film of Naratriptan hydrochloride was prepared by solvent casting method using Hydroxypropylmethyl cellulose (HPMC E6) as film forming polymer and glycerol as plasticizer. To study the effect of independent variables on dependent variables 32 full factorial design was applied using Concentration of HPMC E6 and Concentration of Glycerol as independent variables and disintegration time, folding endurance, tensile strength and cumulative % drug release at 2 min as dependent or response variables. A statistical model incorporating interactive and polynomial terms was utilized to evaluate the responses. Result & conclusion: From the results of statistical evaluation batch F3 was selected as the optimized batch which exhib...
Source: Recent Patents on Drug Delivery and Formulation - Category: Drugs & Pharmacology Tags: Recent Pat Drug Deliv Formul Source Type: research