Glycosylated Chromogranin A in Heart Failure: Implications for Processing and Cardiomyocyte Calcium Homeostasis [Original Article]

Conclusions—
CgA-to-CST conversion in HF is impaired because of hyperglycosylation, which is associated with clinical outcomes in acute HF. The mechanism for increased mortality may be dysregulated cardiomyocyte Ca2+ handling because of reduced CaMKII inhibition.

Source: Circulation: Heart Failure - February 15, 2017 Category: Cardiology Authors: Ottesen, A. H., Carlson, C. R., Louch, W. E., Dahl, M. B., Sandbu, R. A., Johansen, R. F., Jarstadmarken, H., Bjoras, M., Hoiseth, A. D., Brynildsen, J., Sjaastad, I., Stridsberg, M., Omland, T., Christensen, G., Rosjo, H. Tags: Biomarkers, Calcium Cycling/Excitation-Contraction Coupling, Mechanisms, Translational Studies, Heart Failure Original Article Source Type: research