Renin-Angiotensin System Inhibition, Worsening Renal Function, and Outcome in Heart Failure Patients With Reduced and Preserved Ejection Fraction: A Meta-Analysis of Published Study Data [Original Article]

Conclusions—
RAAS inhibitors induce renal dysfunction in both HFREF and HFPEF. However, in contrast to patients with HFREF where mortality increase with WRF is small, HFPEF patients with RAAS inhibitor–induced WRF have an increased mortality risk, without experiencing improved outcome with RAAS inhibition.

Source: Circulation: Heart Failure - February 15, 2017 Category: Cardiology Authors: Beldhuis, I. E., Streng, K. W., Ter Maaten, J. M., Voors, A. A., van der Meer, P., Rossignol, P., McMurray, J. J. V., Damman, K. Tags: Pharmacology, Meta Analysis, Mortality/Survival Original Article Source Type: research