Serum Chloride and Sodium Interplay in Patients With Acute Myocardial Infarction and Heart Failure With Reduced Ejection Fraction: An Analysis From the High-Risk Myocardial Infarction Database Initiative [Original Article]

Conclusions—
In post–myocardial infarction with systolic dysfunction and HF, low serum chloride was associated with mortality (but not hospitalization for HF) in the setting of lower sodium. Overall, chloride and its interaction with sodium did not add clinically relevant prognostic information on top of other well-established prognostic variables. Taken together, these data support an integrated and critical consideration of chloride and sodium interplay.

Source: Circulation: Heart Failure - February 2, 2017 Category: Cardiology Authors: Ferreira, J. P., Girerd, N., Duarte, K., Coiro, S., McMurray, J. J. V., Dargie, H. J., Pitt, B., Dickstein, K., Testani, J. M., Zannad, F., Rossignol, P., for the High-Risk Myocardial Infarction Database Initiative Investigators Tags: Heart Failure, Myocardial Infarction, Mortality/Survival Original Article Source Type: research