A functional connectivity comparison between attention deficit hyperactivity disorder and bipolar disorder in medication-na ïve adolescents with mood fluctuation and attention problems

In order to compare patterns of connectivity between affective and attention networks in adolescents with bipolar disorder (BD) and attention deficit hyperactivity disorder (ADHD), we investigated differences in resting state functional connectivity (RSFC) between these populations. Study participants were medication-na ïve adolescents (aged 13–18 years) with BD (N=22) or ADHD (N=25) and age- and sex-matched healthy adolescents (healthy controls [HC]) (N=22). Forty-seven adolescents with mood fluctuation and attention problems showed increased functional correlation (FC) between two pairs of regions within the a ffective network (AFN), compared to 22 HC: the left orbitofrontal cortex (OFC) to the left thalamus and the left OFC to the right thalamus.
Source: Psychiatry Research: Neuroimaging - Category: Psychiatry Authors: Source Type: research