Pain: Improving opioids

Nature Reviews Neuroscience 18, 130 (2017). doi:10.1038/nrn.2017.22 Author: Katherine Whalley Chronic use of opioid analgesics can cause analgesic tolerance and opioid-induced hyperalgesia (OIH), contributing to dose escalation in patients. Corder et al. here provide evidence that, in mice, these unwanted effects, and the underlying altered circuit plasticity, are mediated by μ opioid receptors (MORs)
Source: Nature Reviews Neuroscience - Category: Neuroscience Authors: Tags: Research Highlight Source Type: research