Pharmacokinetic interactions in mice between irinotecan and MBL ‐II‐141, an ABCG2 inhibitor

ConclusionsThese results may help to anticipate the pharmacokinetic interactions between MBL‐II‐141 and other ABCG2 substrates. The irinotecan‐MBL‐II‐141 interaction is also expected to occur in humans.

Source: Biopharmaceutics and Drug Disposition - February 15, 2017 Category: Drugs & Pharmacology Authors: Emilie H énin, Mylène Honorat, Jérôme Guitton, Attilio Di Pietro, Léa Payen, Michel Tod Tags: Original Paper Source Type: research