Neuropeptide S reduces propofol- or ketamine-induced slow wave states through activation of cognate receptors in the rat
Intracerebroventricular injection of NPS reduces the duration of the ketamine- or thiopental-induced loss of the righting reflex in rats. But the specific EEG activities are unknown. We therefore sought to examine the effects of the NPS-NPSR system on anesthetic-induced characteristics of EEG power spectra and sleep-wake profiles. NPS alone or together with an NPSR antagonist was injected intracerebroventricularly, whereas the propofol (50mg/kg) or ketamine (100mg/kg) was administrated intraperitoneally.
Source: Neuropeptides - Category: Neuroscience Authors: Xiang-Pan Kong, Can Wang, Jun-Fan Xie, Peng Zhao, Li-Rong Dai, Yu-Feng Shao, Jian-Sheng Lin, Yi-Ping Hou Source Type: research
More News: Anesthesia | Anesthesiology | Diprivan | Neurology | Neuroscience | Propofol | Reflex Sympathetic Dystrophy | Sleep Disorders | Sleep Medicine