Spread of tau down neural circuits precedes synapse and neuronal loss in the rTgTauEC mouse model of early Alzheimer's disease

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Graphical abstract
Pickett et al show using high‐resolution array tomography imaging (top) that tau protein (blue) spreads from presynaptic terminals (green) of entorhinal cortex neurons (EC) to postsynaptic terminals (red) in the middle molecular layer of the dentate gyrus (DG) of the hippocampus (bottom) before substantial synapse loss occurs. This demonstrates that presynaptic terminal degeneration is not necessary for tau to spread through neural circuits.

Source: Synapse - February 15, 2017 Category: Neurology Authors: Eleanor K. Pickett, Christopher M. Henstridge, Elizabeth Allison, Rose Pitstick, Amy Pooler, Susanne Wegmann, George Carlson, Bradley T. Hyman, Tara L. Spires ‐Jones Tags: Research Article Source Type: research