Thyroid cytology —nuclear versus architectural atypia within the “Atypia of undetermined significance/follicular lesion of undetermined significance” Bethesda category have significantly different rates of malignancy

CONCLUSIONSThe disparity between malignancy risks within the Bethesda “atypical” category suggests that cytologic (nuclear) atypia is significantly more predictive of malignancy than architectural atypia. This supports the substratification of patients according to risk and a corresponding management approach within this category. A sonographic finding of irregular margins is also predictive for malignancy. Cancer Cytopathol 2017. © 2017 American Cancer Society.

Source: Cancer Cytopathology - February 12, 2017 Category: Pathology Authors: Tiffany Rui Xuan Gan, Min En Nga, Jeffrey Huey Yew Lum, Wendy Meihua Wong, Wee Boon Tan, Rajeev Parameswaran, Kee Yuan Ngiam Tags: Original Article Source Type: research