Structural biology: High-order integration

Nature Reviews Microbiology 15, 133 (2017).
doi:10.1038/nrmicro.2017.3

Author: Ashley York
To establish a lasting infection, lentiviruses, such as HIV-1, stably integrate their DNA into the chromatin of host cells. Integration is mediated by the viral integrase enzyme in a multimeric nucleoprotein complex called the intasome, which assembles onto viral DNA ends to form the strand

Source: Nature Reviews Microbiology - January 22, 2017 Category: Microbiology Authors: Ashley York Tags: Research Highlight Source Type: research