The role of adiponectin receptors in the regulation of synaptic transmission in the hippocampus

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Utilizing fEPSP recording in hippocampal slices the authors showed that adiponectin receptors activation led to a dose‐dependent dampening of LTP. Adiporon (ADPO) had no effect on basal evoked synaptic transmission but it decreased the paired pulse facilitation and the responses during High frequency Stimulation (HFS). A reduction of AMPA receptor‐mediated current is probably involved in the latter effect.

Source: Synapse - February 11, 2017 Category: Neurology Authors: Filippo Weisz, Sonia Piccinin, Dalila Mango, Richard Teke Ngomba, Nicola B. Mercuri, Ferdinando Nicoletti, Robert Nistic ò Tags: Research Article Source Type: research