The association of sleep and physical activity with integrity of white matter microstructure in bipolar disorder patients and healthy controls

We investigate how the sleep disruptions and irregular physical activity levels that are prominent features of bipolar disorder (BD) relate to white matter microstructure in patients and controls. Diffusion tension imaging (DTI) and 14-day actigraphy recordings were obtained in 51 BD I patients and 55 age-and-gender-matched healthy controls. Tract-based spatial statistics (TBSS) was used for voxelwise analysis of the association between fractional anisotropy (FA) and sleep and activity characteristics in the overall sample.

Source: Psychiatry Research: Neuroimaging - February 9, 2017 Category: Psychiatry Authors: Sanne Verkooijen, Remi Stevelink, Lucija Abramovic, Christiaan H. Vinkers, Roel A. Ophoff, Ren é S. Kahn, Marco P.M. Boks, Neeltje E.M. van Haren Source Type: research