Variant Differentiation Patterns in Primary Liver Carcinoma

Hepatocellular carcinoma and intrahepatic cholangiocarcinoma are two distinct forms of primary liver carcinoma recognizable at the microscope by their architectural and cytological characteristics, as well as specific immunohistochemical profiles. This straightforward concept however, is increasing imperiled by the recognition of primary liver carcinomas that do not subscribe to a dichotomous paradigm of differentiation, and instead demonstrate biphenotypic differentiation, stem/ progenitor cell like features or other variant patterns of differentiation.
Source: Seminars in Diagnostic Pathology - Category: Pathology Authors: Source Type: research