Sesamol ameliorates diet ‐induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3‐L1 cells via regulating mitochondria‐lipid metabolism

ConclusionTaken together, this study provides compelling evidence that sesamol supplementation reduced adipocyte size and adipogenesis of diet‐induced obesity by regulating mitochondria lipid metabolism. Supplementation of sesamol, a nature phenol derivative of sesame oil, suppresses obesity and insulin resistance in high‐fat and high‐fructose diet fed mice. Sesamol downregulates lipogenesis in liver, inhibits lipid accumulation and inflammatory responses in white adipose tissue, and decrease adipocytes sizes and “whitening” of brown adipose tissues via improving mitochondria lipid metabolism.
Source: Nahrung / Food - Category: Nutrition Authors: Tags: Research Article Source Type: research