The common dietary flavonoid myricetin attenuates liver fibrosis in carbon tetrachloride treated mice

ConclusionMyricetin inhibits the activation of HSCs and ameliorates CCl4‐induced liver fibrosis in mice and may serve as a potential therapeutic agent in the treatment of liver fibrosis. Myricetin, a natural flavonoid found in berries, vegetables, and herbs, has unique biological activities. Here, it is reported that myricetin inhibits proliferation, migration, and extracellular matrix (ECM) accumulation of activated HSCs stimulated by TGF‐β1 or PDGF in HSCs and reduces the degree of liver fibrosis induced by CCl4 in mice. The mechanism by which it inhibits liver fibrosis is blocking phosphorylation of Smad2/Akt/MAPK.
Source: Nahrung / Food - Category: Nutrition Authors: Tags: Research Article Source Type: research