BDNF ‐induced endocannabinoid release modulates neocortical glutamatergic neurotransmission

This article is protected by copyright. All rights reserved. The authors show that the neurotrophin BDNF modulates presynaptic release probability at cortical glutamatergic synapses via opposing pre‐ and postsynaptic effects. BDNF activates presynaptic trkB receptors to directly enhance release probability, while simultaneously triggering the postsynaptic release of endocannabinoids that act to decrease release via presynaptic CB1 receptors.
Source: Synapse - Category: Neurology Authors: Tags: Research Article Source Type: research