Complementopathies

The complement system is an essential part of the innate immune system that requires careful regulation to ensure responses are appropriately directed against harmful pathogens, while preventing collateral damage to normal host cells and tissues. While deficiency in some components of the complement pathway is associated with increased susceptibility to certain infections, it has also become clear that inappropriate activation of complement is an important contributor to human disease. A number of hematologic disorders are driven by complement, and these disorders may be termed “complementopathies”.

Source: Blood Reviews - February 4, 2017 Category: Hematology Authors: Andrea C. Baines, Robert A. Brodsky Tags: Review Source Type: research