Top-down HPLC-ESI –MS proteomic analysis of saliva of edentulous subjects evidenced high levels of cystatin A, cystatin B and SPRR3

Although complete tooth loss has declined over the last decade, edentulism remains a major disease worldwide, especially among older adults (Douglass, Shih,& Ostry, 2002). Several non-disease factors such as attitude, behavior, dental attendance, characteristics of health care system and socio-demographic factors play important roles in the aetiopathogenesis of edentulism (Emami et al., 2013), but the predominant cause of tooth loss in developed countries is periodontal disease (Famili, Cauley, Suzuki,& Weyant, 2005).

Source: Archives of Oral Biology - January 30, 2017 Category: Dentistry Authors: Barbara Manconi, Barbara Liori, Tiziana Cabras, Federica Iavarone, Armando Manni, Irene Messana, Massimo Castagnola, Alessandra Olianas Source Type: research