Changes to histone modifications following prenatal alcohol exposure: An emerging picture
Epigenetic mechanisms are important for facilitating gene-environment interactions in many disease etiologies, including Fetal Alcohol Spectrum Disorders (FASD). Extensive research into the role of DNA methylation and miRNAs in animal models has illuminated the complex role of these mechanisms in FASD. In contrast, histone modifications have not been as well researched, due in part to being less stable than DNA methylation and less well-characterized in disease. It is now apparent that even changes in transient marks can have profound effects if they alter developmental trajectories.
Source: Alcohol - Category: Addiction Authors: Eric J. Chater-Diehl, Benjamin I. Laufer, Shiva M. Singh Source Type: research
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