Long- but not short-term estradiol treatment induces renal damage in midlife ovariectomized Long-Evans rats

In conclusion, long-term E2 lowered blood pressure but exerted detrimental effects on kidney health in midlife OVX Long-Evans rats, whereas short-term E2 lowered blood pressure and reduced renal damage. These findings highlight that the duration of hormone therapy may be an important factor for renal health in aging postmenopausal women.

Source: AJP: Renal Physiology - February 1, 2017 Category: Urology & Nephrology Authors: Zimmerman, M. A., Hutson, D. D., Trimmer, E. H., Kashyap, S. N., Duong, J. L., Murphy, B., Grissom, E. M., Daniel, J. M., Lindsey, S. H. Tags: RESEARCH ARTICLE Source Type: research