Recombinant Haplotypes Narrow the ARMS2/HTRA1 Association Signal for Age-Related Macular Degeneration [Genetics of Complex Traits]

In this study, we analyzed rare recombinant haplotypes in 16,144 AMD cases and 17,832 controls from the International AMD Genomics Consortium and identified variants in ARMS2 but not HTRA1 to exclusively carry the AMD risk with P-values between 1.0 x 10–773 and 6.7 x 10–5. This now allows prioritization of the gene of interest for subsequent functional studies.
Source: Genetics - Category: Genetics & Stem Cells Authors: Tags: Genetics of Complex Traits Source Type: research