Maltodextrin/ascorbic acid stimulates wound closure by increasing collagen turnover and TGF- β1 expression in vitro and changing the stage of inflammation from chronic to acute in vivo

It has been reported that carbohydrates confer physicochemical properties to the wound environment that improves tissue repair. We evaluated in vitro and in vivo wound healing during maltodextrin/ascorbic acid treatment. In a fibroblast monolayer scratch assay, we demonstrated that maltodextrin/ascorbic acid stimulated monolayer repair by increasing collagen turnover coordinately with TGF- β1 expression (rising TGF-β1 and MMP-1 expression, as well as gelatinase activity, while TIMP-1 was diminished), similar to in vivo trends.

Source: Journal of Tissue Viability - January 31, 2017 Category: Internal Medicine Authors: Rosa M. Salgado, Otilia Cruz-Casta ñeda, Francisco Elizondo-Vázquez, Lucia Pat, Anabel De la Garza, Saúl Cano-Colín, Leticia Baena-Ocampo, Edgar Krötzsch Source Type: research