Factor XI deficiency enhances the pulmonary allergic response to house dust mite in mice independent of factor XII

In conclusion, FXI attenuates part of the allergic response to repeated administration of HDM in the airways by a mechanism that is independent of activation via FXII.

Source: AJP: Lung Cellular and Molecular Physiology - January 31, 2017 Category: Respiratory Medicine Authors: Stroo, I., Yang, J., de Boer, J. D., Roelofs, J. J. T. H., van t Veer, C., Castellino, F. J., Zeerleder, S., van der Poll, T. Tags: RESEARCH ARTICLE Source Type: research