Intra-Articular Vancomycin Powder Eliminates Methicillin-Resistant S. aureus in a Rat Model of a Contaminated Intra-Articular Implant

Conclusions:
In a rat model of a contaminated intra-articular implant, use of intra-articular vancomycin powder in combination with systemic vancomycin completely eliminated MRSA bacterial contamination. Animals treated with systemic vancomycin alone had persistent MRSA contamination.

Clinical Relevance:
This animal study presents data suggesting that the use of intra-articular vancomycin powder for reducing the risk of periprosthetic joint infections should be investigated further in clinical studies.

Source: JBJS - January 31, 2017 Category: Orthopaedics Authors: Edelstein, A. I., Weiner, J. A., Cook, R. W., Chun, D. S., Monroe, E., Mitchell, S. M., Kannan, A., Hsu, W. K., Stulberg, S. D., Hsu, E. L. Tags: Basic Science Scientific Articles Source Type: research