Vancomycin and Ceftazidime in Bone Cement as a Potentially Effective Treatment for Knee Periprosthetic Joint Infection

Conclusions: Bone cement loaded with vancomycin and ceftazidime provided broad-spectrum antibacterial capacity both in vitro and in vivo and was shown to be a potentially effective therapeutic measure in the treatment of knee periprosthetic joint infections. Clinical Relevance: This study confirmed the potential effectiveness of drug delivery from bone cement spacers impregnated with vancomycin and ceftazidime.

http://jbjs.org/cgi/content/short/99/3/223?rss=1

Source: JBJS - January 31, 2017 Category: Orthopaedics Authors: Hsu, Y.-H., Hu, C.-c., Hsieh, P.-H., Shih, H.-N., Ueng, S. W. N., Chang, Y. Tags: Basic Science, Infection, Knee Scientific Articles Source Type: research