Histological Evidence of Muscle Degeneration in Advanced Human Rotator Cuff Disease

Conclusions:
Dramatic degeneration and inflammation of the rotator cuff muscles are characteristics of the most chronic and severe rotator cuff disease states, suggesting that muscle loss is more complicated than, and distinct from, the simple atrophy found in less severe cases.

Clinical Relevance:
In order to address degenerative muscle loss, alternative therapeutic approaches directed at muscle regeneration must be considered if muscle function is to be restored in late-stage rotator cuff disease.

Source: JBJS - January 31, 2017 Category: Orthopaedics Authors: Gibbons, M. C., Singh, A., Anakwenze, O., Cheng, T., Pomerantz, M., Schenk, S., Engler, A. J., Ward, S. R. Tags: Basic Science, Shoulder Scientific Articles Source Type: research