Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats

In conclusion, despite higher caloric intake in glucose-supplemented rats, fructose caused worse metabolic and vascular responses. This may be because of the elevated adiponectin level and the subsequent enhancement of PPARα and eNOS phosphorylation in glucose-supplemented rats. NEW & NOTEWORTHY This is the first study comparing the effects of glucose and fructose consumption on metabolic factors and aortic function in female rats. Our results show that, although total caloric consumption was higher in glucose-supplemented rats, fructose ingestion had a greater impact in inducing metabolic and aortic dysfunction.

http://ajpheart.physiology.org/cgi/content/abstract/312/2/H289?rss=1

Source: AJP: Heart and Circulatory Physiology - January 31, 2017 Category: Cardiology Authors: Sangüesa, G., Shaligram, S., Akther, F., Roglans, N., Laguna, J. C., Rahimian, R., Alegret, M. Tags: Call for Papers: Metabolism, Cell Signaling, and Disease RESEARCH ARTICLE Source Type: research