L5-LDL from ST-elevation myocardial infarction patients induces IL-1{beta} production via LOX-1 and NLRP3 inflammasome activation in macrophages

In conclusion, L5-LDL induces IL-1β production in macrophages by activation of NF-B and caspase-1 through the LOX-1-dependent pathway. This study represents the evidence linking L5-LDL and the inflammatory cytokine IL-1β in STEMI, and identifies L5-LDL as a novel therapeutic target in acute myocardial infarction. NEW & NOTEWORTHY This study represents the evidence linking L5-LDL and the inflammatory cytokine IL-1β in ST-segment elevation myocardial infarction (STEMI). We elucidate the molecular mechanism underlying L5-LDL-induced production of IL-1β in macrophages. The results showed that L5-LDL induced activation of caspase-1 and NF-B through the lectin-type oxidized LDL receptor (LOX-1)-dependent pathway, leading to the production of IL-1β.

http://ajpheart.physiology.org/cgi/content/abstract/312/2/H265?rss=1

Source: AJP: Heart and Circulatory Physiology - January 31, 2017 Category: Cardiology Authors: Yang, T.-C., Chang, P.-Y., Lu, S.-C. Tags: Call for Papers: Metabolism, Cell Signaling, and Disease RESEARCH ARTICLE Source Type: research