Chymase-dependent production of angiotensin II: an old enzyme in old hearts

In conclusion, local formation of Ang II is increased in aged hearts, and chymase is primarily responsible for this increase. Chronic exercise is able to normalize the age-dependent alterations via compromising chymase/Ang II/angiotensin type 1 receptor/Nox actions while promoting ACE2/Ang 1-7/MasR signaling.
NEW & NOTEWORTHY Aging increases angiotensin-converting enzyme (ACE)-independent production of cardiac angiotensin II (Ang II), a response that is driven by chymase in an exercise-reversible manner. These findings highlight chymase, in addition to ACE, as an important therapeutic target in the treatment and prevention of Ang II-induced deterioration of cardiac function in the elderly.

Source: AJP: Heart and Circulatory Physiology - January 31, 2017 Category: Cardiology Authors: Froogh, G., Pinto, J. T., Le, Y., Kandhi, S., Aleligne, Y., Huang, A., Sun, D. Tags: RESEARCH ARTICLE Source Type: research