Lnc-ing ROR1 –HER3 and Hippo signalling in metastasis

Nature Cell Biology 19, 81 (2017).
doi:10.1038/ncb3467

Authors: Wei Zhuo & Yibin Kang
Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cancer progression. The previously uncharacterized lncRNA MAYA is now shown to promote bone metastasis by bridging ROR1–HER3 and Hippo–YAP pathways. Neuregulin-induced HER3 phosphorylation by ROR1 recruits a MAYA-containing protein complex to methylate Hippo/MST1 and activate YAP target genes that are essential for bone metastasis.

Source: Nature Cell Biology - January 30, 2017 Category: Cytology Authors: Wei Zhuo Yibin Kang Tags: News and Views Source Type: research